ALK2 Antibody / ACVR1
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1 (activin A type I receptor) signals a particular transcriptional response in concert with activin type II receptors.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:500-1:1000
UniProt
Q04771
Host
Rabbit
Reactivity
Human, Rat
Immunogen
A portion of amino acids 6-34 from the human protein was used as the immunogen for this ALK2 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the ALK2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This ALK2 antibody is available for research use only.
Storage Conditions
Aliquot the ALK2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the ALK2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of 1) human A549, 2) human HepG2 and 3) rat testis lysate with ALK2 antibody at 1:1000. Predicted molecular weight ~57 kDa.
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