Thioredoxin Antibody / TRX / TXN
Thioredoxin / TRX / TXN participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000-1:2000
UniProt
P10599
Host
Mouse
Reactivity
Human
Immunogen
Recominant human Thioredoxin protein was used as the immunogen for the Thioredoxin antibody.
Clonality
Monoclonal
Isotype
IgG1 κ
Clone
1850CT339.14.1
Applications
WB
Purity
Protein G purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Thioredoxin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Thioredoxin antibody is available for research use only.
Storage Conditions
Aliquot the Thioredoxin antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Image Legend
Western blot testing of human 1) SH-SY5Y, 2) A431 and 3) HeLa cell lysate with Thioredoxin antibody at 1:2000. Predicted molecular weight ~12 kDa.
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