DLL4 Antibody

Delta-like protein 4 is involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation is required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate.

Product Specifications

CAS Number

9007-83-4

Specifications

Western blot: 1:1000-1:2000

UniProt

Q9NR61

Host

Rabbit

Reactivity

Mouse, Rat

Immunogen

Recombinant human Delta-like protein 4 protein was used as the immunogen for the DLL4 antibody.

Clonality

Polyclonal

Isotype

Applications

Purity

Antigen affinity

Format

Antigen affinity purified

Buffer

In 1X PBS, pH 7.4, with 0.09% sodium azide

Reconstitution

Aliquot the DLL4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This DLL4 antibody is available for research use only.

Storage Conditions

Aliquot the DLL4 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

In 1X PBS, pH 7.4, with 0.09% sodium azide

Applications Notes

The stated application concentrations are suggested starting points. Titration of the DLL4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Prediction Reactivity

Human

Image Legend

Western blot testing of 1) mouse kidney, 2) mouse lung and 3) rat lung tissue lysate with DLL4 antibody at 1:2000. Predicted molecular weight: 75-85 kDa.