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TLR3 Antibody

Toll like Receptor 3 is a key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response. [UniProt]

Product Specifications

CAS Number

9007-83-4

Specifications

Western blot: 1:1000

UniProt

O15455

Host

Mouse

Reactivity

Human

Immunogen

A human recombinant partial protein was used as the immunogen for this TLR3 antibody.

Clonality

Monoclonal

Isotype

IgG2b

Clone

2F10-B8-G9

Applications

WB

Purity

Protein G affinity

Format

Purified

Buffer

Antibody in PBS with 50% Glycerol and 0.03% ProClin 300

Reconstitution

Store the TLR3 antibody at -20oC.

Limitations

This TLR3 antibody is available for research use only.

Storage Conditions

Store the TLR3 antibody at -20°C.

Formulation

In PBS with 50% glycerol and 0.03% ProClin 300

Applications Notes

The stated application concentrations are suggested starting points. Titration of the TLR3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Image Legend

Western blot testing of TLR3 A) transfected and (B) untransfected CHO-K1 cell lysate with TLR3 antibody at 1:1000. Expected molecular weight of the partial protein: ~50 kDa.

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