HtrA2 Antibody

Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive. [UniProt]

Product Specifications

CAS Number

9007-83-4

Specifications

Western blot: 1:1000

UniProt

O43464

Host

Mouse

Reactivity

Mouse, Hamster

Immunogen

A human recombinant protein was used as the immunogen for this HtrA2 antibody.

Clonality

Monoclonal

Isotype

IgG1

Clone

1H8-C12-F8

Applications

Purity

Protein G affinity

Format

Purified

Buffer

Antibody in PBS with 50% Glycerol and 0.02% sodium azide

Reconstitution

Store the HtrA2 antibody at -20oC.

Limitations

This HtrA antibody is available for research use only.

Storage Conditions

Store the HtrA2 antibody at -20°C.

Formulation

In PBS with 50% glycerol and 0.02% sodium azide

Applications Notes

The stated application concentrations are suggested starting points. Titration of the HtrA2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Prediction Reactivity

Human

Image Legend

Western blot testing of hamster CHO-K1, mouse MEF and mouse NIH3T3 cell lysates using HtrA2 antibody at 1:1000. Predicted molecular weight: 38-49 kDa.