S100 beta Antibody
Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.
Product Specifications
Specifications
Western blot: 1:500
UniProt
P04271
Host
Mouse
Reactivity
Rat
Immunogen
A S100B synthetic peptide was used as the immunogen for this S100 beta antibody.
Clonality
Monoclonal
Isotype
LgG2b
Clone
5G3-C11
Applications
WB
Purity
Protein G affinity
Format
Purified
Buffer
Antibody in PBS with 50% Glycerol and 0.03% ProClin 300
Reconstitution
Store the S100 beta antibody at -20oC.
Limitations
This S100 beta antibody is available for research use only.
Storage Conditions
Store the S100 beta antibody at -20°C.
Product Datasheet
https://www.nsjbio.com/tds-pdf/s100-beta-antibody-5g3-c11-f54011
Formulation
In PBS with 50% glycerol and 0.03% ProClin 300
Applications Notes
Prediction Reactivity
Human
CAS Number
9007-83-4
Image Legend
Western blot testing of rat brain lysate with S100 beta antibody at 1:500 diluted. Predicted molecular weight ~11 kDa.
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