PACSIN2 Antibody
Protein kinase C and casein kinase substrate in neurons protein 2 is a lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle- mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:500-1:1000, IHC (FFPE) : 1:50-100, Immunofluorescence: 1:100
UniProt
Q9UNF0
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 342-371 from the human protein was used as the immunogen for the PACSIN2 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC-P, IF
Purity
Protein G affinity chromatography
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the PACSIN2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This PACSIN2 antibody is available for research use only.
Storage Conditions
Aliquot the PACSIN2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the PACSIN2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasmic
Image Legend
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