PRDM16 Antibody
PR domain zinc finger protein 16 binds DNA and functions as a transcriptional regulator. Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism. Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells. Functions also as a repressor of TGF-beta signaling. Isoform 4 may regulate granulocytes differentiation.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:2000-4000
UniProt
Q9HAZ2
Host
Mouse
Reactivity
Human
Immunogen
A partial recombinant protein corresponding to amino acids 779-996 from the human protein was used as the immunogen for the PRDM16 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
1740CT793.52.44
Applications
WB
Purity
Protein G affinity chromatography
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the PRDM16 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This PRDM16 antibody is available for research use only.
Storage Conditions
Aliquot the PRDM16 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the PRDM16 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of human 1) Jurkat and 2) K562 cell lysate with PRDM16 antibody at 1:4000. Predicted molecular weight: 140 kDa.
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