TPX2 Antibody / p100
Targeting protein for Xklp2, also called TPX2 and p100, is a spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000-2000
UniProt
Q9ULW0
Host
Mouse
Reactivity
Human
Immunogen
A partial recombinant protein corresponding to amino acids 1-531 from the human protein was used as the immunogen for the TPX2 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
1696CT464.66.9
Applications
WB
Purity
Protein G affinity chromatography
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the TPX2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This TPX2 antibody is available for research use only.
Storage Conditions
Aliquot the TPX2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the TPX2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of human 1) HT-29, 2) K562, 3) MCF-7 and 4) Raji cell lysate with TPX2 antibody at 1:2000. Predicted molecular weight: 86 kDa.
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