Titin Antibody / TTN
Titin is a key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase.
Product Specifications
CAS Number
9007-83-4
Specifications
IHC (FFPE) : 1:25
Gene ID
7273
UniProt
Q8WZ42
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 7169-7203 from the human protein was used as the immunogen for the Titin antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Titin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Titin antibody is available for research use only.
Storage Conditions
Aliquot the Titin antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the Titin antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Mouse
Image Legend
IHC testing of FFPE human skeletal muscle with Titin antibody at 1:25. HIER: steamed in pH6 citrate buffer.
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