NMNAT1 Antibody
Nicotinamide mononucleotide adenylyltransferase 1 catalyzes the formation of NAD (+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD (+) . For the pyrophosphorolytic activity, prefers NAD (+) and NAAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Fails to cleave phosphorylated dinucleotides NADP (+), NADPH and NAADP (+) . Protects against axonal degeneration following mechanical or toxic insults.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000-2000
UniProt
Q9HAN9
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 171-201 from the human protein was used as the immunogen for the NMNAT1 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the NMNAT1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This NMNAT1 antibody is available for research use only.
Storage Conditions
Aliquot the NMNAT1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the NMNAT1 antibody may be required due to differences in protocols and substrate sensitivity.
Prediction Reactivity
Bovine
Image Legend
Western blot testing of human brain lysate with NMNAT1 antibody at 1:2000. Predicted molecular weight: 32 kDa.
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