XRN1 Antibody
5'-3' Exoribonuclease 1 is a major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity) . Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) .
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000-2000
UniProt
Q8IZH2
Host
Mouse
Reactivity
Human
Immunogen
A human recombinant protein corresponding to amino acids 1455-1706 was used as the immunogen for the XRN1 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
1647CT536.85.48
Applications
WB
Purity
Protein G affinity chromatography
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the XRN1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This XRN1 antibody is available for research use only.
Storage Conditions
Aliquot the XRN1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the XRN1 antibody may be required due to differences in protocols and substrate sensitivity.
Image Legend
Western blot testing of human 1) K562 and 2) MCF7 cell lysate with XRN1 antibody at 1:2000. Predicted molecular weight: 194 kDa.
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