BANP Antibody
Btg3-associated nuclear protein controls V (D) J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest (By similarity) .
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:500-1000, IHC (FFPE) : 1:25
UniProt
Q8N9N5
Host
Mouse
Reactivity
Human
Immunogen
A human recombinant protein of amino acids 30-390 was used as the immunogen for the BANP antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
1524CT337.6.32
Applications
WB, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the BANP antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This BANP antibody is available for research use only.
Storage Conditions
Aliquot the BANP antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the BANP antibody may be required due to differences in protocols and substrate sensitivity.
Image Legend
Western blot testing of human HeLa cell lysate with BANP antibody at 1:1000. Predicted molecular weight: 56 kDa, observed here at ~70 kDa.
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