PINK1 Antibody
PINK1 protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PARK2. Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2. Activates PARK2 in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PARK2 and (2) mediating phosphorylation of ubiquitin, converting PARK2 to its fully-active form. [UniProt]
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:500-1:2000, IHC (Paraffin) : 1:10-1:50
UniProt
Q9BXM7
Host
Mouse
Reactivity
Human, Mouse
Immunogen
Recombinant protein was used to produced this PINK1 antibody.
Clonality
Monoclonal
Isotype
IgG1
Clone
38CT20.8.5
Applications
WB, IHC, ELISA
Purity
Ascites
Format
Ascites
Buffer
In ascites with 0.09% sodium azide
Reconstitution
Aliquot the PINK1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This PINK1 antibody is available for research use only.
Storage Conditions
Aliquot the PINK1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In ascites with 0.09% sodium azide
Applications Notes
Titration of the PINK1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
IHC analysis of FFPE human brain cortex tissue stained with PINK1 antibody
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