IL-1B Antibody
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE) . This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq].
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:2000-1:4000
UniProt
P01584
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 148-174 from the human protein was used as the immunogen for this IL-1B antibody.
Clonality
Monoclonal
Isotype
IgG1
Clone
614CT4.3.1
Applications
WB, ELISA
Purity
Ascites
Format
Ascites
Buffer
In ascites with 0.09% sodium azide
Reconstitution
Aliquot the IL-1B antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This IL-1B antibody is available for research use only.
Storage Conditions
Aliquot the IL-1B antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In ascites with 0.09% sodium azide
Applications Notes
Titration of the IL-1B antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Primate, Rabbit
Image Legend
IL-1B antibody 293 cell lysate transiently transfected with the IL1B gene. Predicted molecular weight: 31 kDa (precursor) and 17 kDa (mature) .
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