Cortactin Antibody
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000-1:8000
UniProt
Q14247
Host
Mouse
Reactivity
Human
Immunogen
Purified His-tagged Cortactin protein fragment was used to produced this monoclonal Cortactin antibody.
Clonality
Monoclonal
Isotype
IgM
Clone
401CT8.6.3
Applications
WB, ELISA
Purity
Ascites
Format
Ascites
Buffer
In ascites with 0.09% sodium azide
Reconstitution
Aliquot the Cortactin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Cortactin antibody is available for research use only.
Storage Conditions
Aliquot the Cortactin antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In ascites with 0.09% sodium azide
Applications Notes
Titration of the Cortactin antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Cortactin antibody western blot analysis in MDA-MB231 lysate. Molecular weight: routinely observed at ~80kDa.
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