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PR Antibody / Progesterone Receptor / Isoform A & B

This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. The location of transcription initiation for isoform A has not been clearly determined.

Product Specifications

CAS Number

9007-83-4

Specifications

Western blot: 1:100-1:3200

UniProt

P06401

Host

Mouse

Reactivity

Human

Immunogen

A portion of amino acids 349-377 from the human protein was used as the immunogen for this PR antibody.

Clonality

Monoclonal

Isotype

IgM

Clone

312CT8.2.1.6

Applications

WB, ELISA

Purity

Ascites

Format

Ascites

Buffer

In ascites with 0.09% sodium azide

Reconstitution

Aliquot the PR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This PR antibody is available for research use only.

Storage Conditions

Aliquot the PR antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

In ascites with 0.09% sodium azide

Applications Notes

Titration of the PR antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Image Legend

PR antibody western blot analysis in SK-BR-3 lysate. Expected molecular weight: 82-94 kDa (isoform A) and 99-120 kDa (isoform B) .

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