PR Antibody / Progesterone Receptor / Isoform A & B
This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. The location of transcription initiation for isoform A has not been clearly determined.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:100-1:3200
UniProt
P06401
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 349-377 from the human protein was used as the immunogen for this PR antibody.
Clonality
Monoclonal
Isotype
IgM
Clone
312CT8.2.1.6
Applications
WB, ELISA
Purity
Ascites
Format
Ascites
Buffer
In ascites with 0.09% sodium azide
Reconstitution
Aliquot the PR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This PR antibody is available for research use only.
Storage Conditions
Aliquot the PR antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In ascites with 0.09% sodium azide
Applications Notes
Titration of the PR antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
PR antibody western blot analysis in SK-BR-3 lysate. Expected molecular weight: 82-94 kDa (isoform A) and 99-120 kDa (isoform B) .
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