C-RET Antibody
This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:500-1:16000, IHC (Paraffin) : 1:50-1:100, Immunofluorescence: 1:10-1:50
UniProt
P07949
Host
Mouse
Reactivity
Human
Immunogen
This c-RET antibody was raised using purified His-tagged recombinant human c-RET.
Clonality
Monoclonal
Isotype
IgM k
Clone
188CT11.2.3
Applications
WB, IHC, IF, ELISA
Purity
Ascites
Format
Ascites
Buffer
In ascites with 0.09% sodium azide
Reconstitution
Aliquot the c-RET antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This c-RET antibody is available for research use only.
Storage Conditions
Aliquot the c-RET antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In ascites with 0.09% sodium azide
Applications Notes
Titration of the c-RET antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of human A549 cell lysate with c-RET antibody.
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