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BMI1 Antibody

Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.

Product Specifications

UniProt

P35226

Host

Rabbit

Immunogen

This BMI1 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 230-265 amino acids from the C-terminal region of human BMI1.

Clonality

Polyclonal

Isotype

Ig

Applications

WB, ELISA

Format

Antigen affinity purified

Buffer

In 1X PBS, pH 7.4, with 0.09% sodium azide

Reconstitution

Aliquot the BMI1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This BMI1 antibody is available for research use only.

CAS Number

9007-83-4

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