FBXW7 Antibody
Substrate recognition component of an SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination. Identified substrates include cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. [UniProt]
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:2000
UniProt
Q969H0
Host
Rabbit
Reactivity
Human
Immunogen
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the FBXW7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This FBXW7 antibody is available for research use only.
Storage Conditions
Aliquot the FBXW7 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the FBXW7 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of FBXW7 antibody at 1:2000 dilution + HeLa lysate; Predicted molecular weight: 80 kDa (alpha), 70 kDa (beta) .
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