FBXW7 Antibody
Substrate recognition component of an SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination. Identified substrates include cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. [UniProt]
Product Specifications
UniProt
Q969H0
Host
Rabbit
Immunogen
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the FBXW7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This FBXW7 antibody is available for research use only.
CAS Number
9007-83-4
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