KDM6A Antibody
Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:2000
UniProt
O15550
Host
Rabbit
Reactivity
Human
Immunogen
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the KDM6A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This KDM6A antibody is available for research use only.
Storage Conditions
Aliquot the KDM6A antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the KDM6A antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of KDM6A antibody at 1:2000 dilution. Lane 1: human liver lysate; 2: HeLa lysate; Predicted molecular weight ~ 154 kDa.
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