Lamin A/C Antibody
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for osteoblastogenesis and bone formation. Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:500-1000
UniProt
P02545
Host
Rabbit
Reactivity
Human
Immunogen
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Lamin A/C antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Lamin A/C antibody is available for research use only.
Storage Conditions
Aliquot the Lamin A/C antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the Lamin A/C antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of Lamin A/C antibody at 1:500 dilution. Lane 1: A431 lysate; 2: HepG2 lysate; Predicted band size : 70 kDa.
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