DKK1 Antibody
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. [UniProt]
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000-1:4000
UniProt
O94907
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This DKK1 antibody was produced from a rabbit immunized with a recombinant protein of human DKK1.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the DKK1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This DKK1 antibody is available for research use only.
Storage Conditions
Aliquot the DKK1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the DKK1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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