Suz12 Antibody

Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity) . Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8.

Product Specifications

CAS Number

9007-83-4

Specifications

Western blot: 1:1000

UniProt

Q80U70

Host

Rabbit

Reactivity

Mouse

Immunogen

This Suz12 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 496-530 amino acids from the mouse protein.

Clonality

Polyclonal

Isotype

Applications

WB, ELISA

Purity

Antigen affinity

Format

Antigen affinity purified

Buffer

In 1X PBS, pH 7.4, with 0.09% sodium azide

Reconstitution

Aliquot the Suz12 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This Suz12 antibody is available for research use only.

Storage Conditions

Aliquot the Suz12 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

In 1X PBS, pH 7.4, with 0.09% sodium azide

Applications Notes

Titration of the Suz12 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Prediction Reactivity

Human

Image Legend

Western blot testing of Suz12 antibody at 1:1000 dilution. Lane 1: mouse F9 lysate; 2: human HeLa lysate; 3: human MCF-7 lysate; Observed molecular weight 83~95 kDa.