Hes1 Antibody
Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 (By similarity) . Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross- link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity) .
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:500
UniProt
P35428
Host
Rabbit
Reactivity
Mouse
Immunogen
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Hes1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Hes1 antibody is available for research use only.
Storage Conditions
Aliquot the Hes1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the Hes1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Human, Rat
Image Legend
Western blot analysis of lysate from mouse kidney tissue lysate using Hes1 antibody diluted at 1:500. Predicted molecular weight: 30-35 kDa.
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