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OPA1 Antibody

Dynamin-related GTPase required for mitochondrial fusion and regulation of apoptosis. May form a diffusion barrier for proteins stored in mitochondrial cristae. Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space.

Product Specifications

CAS Number

9007-83-4

Specifications

Western blot: 1:1000

UniProt

O60313

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

This OPA1 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 895-929 amino acids from the C-terminal region of human OPA1, form S1.

Clonality

Polyclonal

Isotype

Ig

Applications

WB, ELISA

Purity

Antigen affinity

Format

Antigen affinity purified

Buffer

In 1X PBS, pH 7.4, with 0.09% sodium azide

Reconstitution

Aliquot the OPA1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This OPA1 antibody is available for research use only.

Storage Conditions

Aliquot the OPA1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

In 1X PBS, pH 7.4, with 0.09% sodium azide

Applications Notes

Titration of the OPA1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Prediction Reactivity

Chicken, Zebrafish

Image Legend

Western blot analysis of lysate from (1) HeLa cell line, (2) mouse brain and (3) rat brain tissue lysate using OPA1 antibody at 1:1000.

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