FIS1 Antibody / TTC11

Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin- related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.

Product Specifications

CAS Number

9007-83-4

Specifications

Western blot: 1:1000

UniProt

Q9Y3D6

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

This FIS1 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 6-40 amino acids from the N-terminal region of human FIS1.

Clonality

Polyclonal

Isotype

Applications

WB, ELISA

Purity

Antigen affinity

Format

Antigen affinity purified

Buffer

In 1X PBS, pH 7.4, with 0.09% sodium azide

Reconstitution

Aliquot the FIS1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This FIS1 antibody is available for research use only.

Storage Conditions

Aliquot the FIS1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

In 1X PBS, pH 7.4, with 0.09% sodium azide

Applications Notes

Titration of the FIS1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Image Legend

Western blot analysis of lysate from (1) Raji cell line, (2) human spleen, (3) mouse brain and (4) rat brain tissue lysate using FIS1 antibody at 1:1000.