STAT3 Antibody
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6) - responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity) .
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
P40763
Host
Mouse
Reactivity
Human
Immunogen
This STAT3 antibody was produced from a mouse immunized with a recombinant protein from human.
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
1200CT146.104.153
Applications
WB, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS pH 7.4 with 0.09% sodium azide
Reconstitution
Aliquot the STAT3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This STAT3 antibody is available for research use only.
Storage Conditions
Aliquot the STAT3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the STAT3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Mouse, Rat, Pig
Image Legend
Western blot analysis of lysate from CEM, HeLa cell line (left to right) using STAT3 antibody at 1:1000 for each lane.
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