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Anti-Mouse RANKL/CD254 Antibody (IK22/5)

Anti-Mouse RANKL/CD254 Antibody (IK22/5) is an anti-mouse RANKL/CD254 IgG2a monoclonal antibody. Anti-Mouse RANKL/CD254 Antibody (IK22/5) inhibits osteoclast formation and activity by specifically blocking the binding of RANKL and RANK. Anti-Mouse RANKL/CD254 Antibody (IK22/5) can inhibit the expression of MuRF1/Trogin-1 and activation of NF-κB. Anti-Mouse RANKL/CD254 Antibody (IK22/5) can be used for research on cancer such as melanoma or colon cancer and osteoporosis[1][2][3].

Product Specifications

CAS Number

9007-83-4

UNSPSC

12352203

Target

E1/E2/E3 Enzyme; NF-κB; RANKL/RANK

Type

Inhibitory Antibodies

Related Pathways

Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/anti-mouse-rankl-cd254-antibody-ik22-5.html

Purity

95.00

Solubility

10 mM in DMSO

Smiles

[Anti-MouseRANKL/CD254Antibody(IK22/5)]

Molecular Weight

(150 kDa)

References & Citations

[1]Kamijo S, et al. Amelioration of bone loss in collagen-induced arthritis by neutralizing anti-RANKL monoclonal antibody. Biochem Biophys Res Commun. 2006 Aug 18;347 (1) :124-32. |[2]Ahern E, et al. Co-administration of RANKL and CTLA4 Antibodies Enhances Lymphocyte-Mediated Antitumor Immunity in Mice. Clin Cancer Res. 2017 Oct 1;23 (19) :5789-5801.|[3]Xiong J, et al. RANKL Mediates Muscle Atrophy and Dysfunction in a Cigarette Smoke-induced Model of Chronic Obstructive Pulmonary Disease. Am J Respir Cell Mol Biol. 2021 May;64 (5) :617-628.

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4°C for 2 years, do not freeze

Scientific Category

Inhibitory Antibodies

Clinical Information

No Development Reported

Isoform

NF-κB

Available Sizes

Frequently Asked Questions

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