PIN1 Antibody
Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.
Product Specifications
UniProt
Q13526
Host
Mouse
Immunogen
Purified His-tagged protein was used to produced this monoclonal PIN1 antibody.
Clonality
Monoclonal
Isotype
IgG1
Applications
IHC, WB, ELISA
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the PIN1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This PIN1 antibody is available for research use only.
CAS Number
9007-83-4
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