PIN1 Antibody
Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.
Product Specifications
CAS Number
9007-83-4
Specifications
IHC (Paraffin) : 1:25, Western blot: 1:1000
UniProt
Q13526
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
Purified His-tagged protein was used to produced this monoclonal PIN1 antibody.
Clonality
Monoclonal
Isotype
IgG1
Clone
855CT1.7.5
Applications
IHC, WB, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the PIN1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This PIN1 antibody is available for research use only.
Storage Conditions
Aliquot the PIN1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the PIN1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Immunohistochemical analysis of paraffin-embedded human breast using PIN1 antibody at 1:25 dilution.
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