TICAM1 Antibody
Involved in innate immunity against invading pathogens. Adapter used by <a href=../search_result.php?search_txt=TLR>TLR3</a> and <a href=../search_result.php?search_txt=TLR>TLR4</a> (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins <a href=../search_result.php?search_txt=Tbk1>TBK1</a>, TRAF6 and <a href=../search_result.php?search_txt=ripk>RIPK1</a>, which in turn, lead to the activation of transcription factors IRF3 and IRF7, <a href=../search_result.php?search_txt=nf-kb>NF-kappa-B</a> and FADD respectively.
Product Specifications
UniProt
Q8IUC6
Host
Rabbit
Immunogen
A portion of amino acids 115-143 from the human protein was used as the immunogen for this TICAM1 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the TICAM1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This TICAM1 antibody is available for research use only.
CAS Number
9007-83-4
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