IkBa Antibody
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
P25963
Host
Mouse
Reactivity
Human
Immunogen
Purified His-tagged protein was used to produced this monoclonal IkB alpha antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
1121CT8.6.1
Applications
WB, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS pH 7.4 with 0.09% sodium azide
Reconstitution
Aliquot the IkBa antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This IkBa antibody is available for research use only.
Storage Conditions
Aliquot the IkBa antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the IkBa antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
IkBa antibody western blot analysis in human HeLa and mouse NIH3T3 cell lysate.
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