CCND1 Antibody
Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin D1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. Mutations, amplification and overexpression of the gene encoding this protein, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
P24385
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A portion of amino acids 264-292 from the human protein was used as the immunogen for this CCND1 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the CCND1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This CCND1 antibody is available for research use only.
Storage Conditions
Aliquot the CCND1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the CCND1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Bovine
Image Legend
CCND1 antibody western blot analysis in (1) human A431, (2) mouse L929 and (3) rat C6 lysate. Predicted molecular weight: 32-36 kDa.
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