TSC1 Antibody
In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity) . Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity) .
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
Q9EP53
Host
Rabbit
Reactivity
Mouse
Immunogen
A portion of amino acids 1117-1144 from the mouse protein was used as the immunogen for this TSC1 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the TSC1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This TSC1 antibody is available for research use only.
Storage Conditions
Aliquot the TSC1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the TSC1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
TSC1 antibody western blot analysis in mouse liver tissue lysate. Expected/observed molecular weight: 130~150kDa.
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