P27Kip1 Antibody
Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E-and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of cyclin D-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
P46414
Host
Rabbit
Reactivity
Mouse
Immunogen
A portion of amino acids 175-197 from the mouse protein was used as the immunogen for this p27Kip1 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the p27Kip1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This p27Kip1 antibody is available for research use only.
Storage Conditions
Aliquot the p27Kip1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the p27Kip1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
P27Kip1 antibody western blot analysis in mouse heart tissue lysate. Predicted molecular weight ~27kDa.
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