AANAT Antibody
Serotonin N-acetyltransferase/AANAT belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
Q16613
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 27-54 from the human protein was used as the immunogen for this AANAT antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the AANAT antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This AANAT antibody is available for research use only.
Storage Conditions
Aliquot the AANAT antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the AANAT antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot analysis of AANAT antibody and human Y79 lysate. Predicted molecular weight ~23 kDa.
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