AANAT Antibody
Serotonin N-acetyltransferase/AANAT belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome.
Product Specifications
UniProt
Q16613
Host
Rabbit
Immunogen
A portion of amino acids 27-54 from the human protein was used as the immunogen for this AANAT antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the AANAT antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This AANAT antibody is available for research use only.
CAS Number
9007-83-4
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