Acrosin Antibody / ACR
Acrosin/ACR is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:50-1:100
UniProt
P10323
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 387-416 from the human protein was used as the immunogen for this Acrosin antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Acrosin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Acrosin antibody is available for research use only.
Storage Conditions
Aliquot the Acrosin antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the Acrosin antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasmic
Image Legend
Western blot analysis of Acrosin antibody and human Jurkat lysate. Predicted molecular weight ~46 kDa.
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