Amyloid beta Precusor Protein Antibody

APP is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy) .

Product Specifications

CAS Number

9007-83-4

Specifications

Western blot: 1:1000

UniProt

P05067

Host

Rabbit

Reactivity

Human

Immunogen

A portion of amino acids 735-763 from the human protein was used as the immunogen for this Amyloid beta precusor protein antibody.

Clonality

Polyclonal

Isotype

Applications

WB, ELISA

Purity

Antigen affinity

Format

Antigen affinity purified

Buffer

In 1X PBS, pH 7.4, with 0.09% sodium azide

Reconstitution

Aliquot the Amyloid beta precusor protein antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This Amyloid beta precusor protein antibody is available for research use only.

Storage Conditions

Aliquot the Amyloid beta precusor protein antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

In 1X PBS, pH 7.4, with 0.09% sodium azide

Applications Notes

Titration of the Amyloid beta precusor protein antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Prediction Reactivity

Mouse, Pig, Rat

Image Legend

Western blot analysis of Amyloid beta precusor protein antibody in T47D lysate. Predicted molecular weight 79~120kDa depending on glycosylation level.