LDLR Antibody
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, Flow Cytometry: 1:10-1:50
UniProt
P01130
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 391-419 from the human protein was used as the immunogen for this LDLR antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, FACS, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the LDLR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This LDLR antibody is available for research use only.
Storage Conditions
Aliquot the LDLR antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the LDLR antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Rat, Pig, Rabbit, Hamster, Xenopus
Image Legend
Western blot analysis of LDLR antibody and mouse lung tissue lysate. Expected molecular weight: 95-160 kDa depending on glycosylation level.
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