P73 Antibody
TP73 is tumor protein p73, which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73 and have high sequence similarity to one another, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways involving direct or indirect protein interactions, resulting in regulation of the same target gene promoters or regulation of each other's promoters. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:50-1:100, Flow Cytometry: 1:10-1:50, Immunofluorescence: 1:10-1:50
UniProt
O15350
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 288-317 from the human protein was used as the immunogen for this p73 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IHC, FACS, IF, WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the p73 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This p73 antibody is available for research use only.
Storage Conditions
Aliquot the p73 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the p73 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
P73 antibody western blot analysis in 1) human K562 cell line and 2) mouse brain tissue lysate.
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