UHRF1 Antibody
UHRF1 is a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone acetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, Flow Cytometry: 1:10-1:50, Immunofluorescence: 1:10-1:50
UniProt
Q96T88
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 229-257 from the human protein was used as the immunogen for this UHRF1 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
FACS, IF, WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the UHRF1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This UHRF1 antibody is available for research use only.
Storage Conditions
Aliquot the UHRF1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the UHRF1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
UHRF1 antibody western blot analysis of HeLa lysate. Predicted/observed molecular weight: ~91/91-106kDa.
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