ZAK Antibody / MLKLAK
ZAK/MLKLAK is a member of the MAPKKK family of signal transduction molecules. It possesses an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM) . This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:50-1:100
UniProt
Q9NYL2
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 271-300 from the human protein was used as the immunogen for this ZAK antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the ZAK antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This ZAK antibody is available for research use only.
Storage Conditions
Aliquot the ZAK antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the ZAK antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Mouse
Image Legend
Western blot analysis of ZAK antibody and human HepG2 lysate. There are three isoforms of ZAK, visualized at ~91 kDa, ~51 kDa and ~35 kDa.
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