NIK Antibody (Nck-interacting kinase)
HGK/NIK, a member of the STE20 subfamily of Ser/Thr protein kinases, may play a role in the response to environmental stress and cytokines such as TNF-alpha. It appears to act upstream of the JUN N-terminal pathway. This protein is thought to interact with the SH3 domain of the adapter proteins Nck. HGK/NIK binds, via its CNH regulatory domain, to the N-terminal region of SPG3A. Expression appears to be ubiquitous, expressed in all tissue types examined. Isoform 5 appears to be more abundant in the brain, and isoform 4 is predominant in the liver, skeletal muscle and placenta.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
O95819
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 618-649 from the human protein was used as the immunogen for this NIK antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the NIK antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This NIK antibody is available for research use only.
Storage Conditions
Aliquot the NIK antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the NIK antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot analysis of NIK antibody and Jurkat lysate. Predicted molecular weight ~140 kDa.
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Frequently Asked Questions
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