TG2 Antibody / Transglutaminase 2
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. TGM2 acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. It has been identified as the autoantigen implicated in celiac disease.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
P21980
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 413-442 from the human protein was used as the immunogen for this TG2 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
SAS immunoprecipitation purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the TG2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This TG2 antibody is available for research use only.
Storage Conditions
Aliquot the TG2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the TG2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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