ACE Antibody / Angiotensin-Converting Enzyme
ACE is an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes - the somatic form and the testicular form that are equally active.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
P12821
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 1274-1306 from the human protein was used as the immunogen for this ACE antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the ACE antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This ACE antibody is available for research use only.
Storage Conditions
Aliquot the ACE antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the ACE antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot analysis of ACE antibody and mouse lung tissue lysate. Expected molecular weight 140-170 kDa.
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