Clascoterone-d6
Clascoterone-d6 (Cortexolone 17 alpha-propionate-d6) is deuterium labeled Clascoterone. Clascoterone (Cortexolone 17 alpha-propionate; Cortexolone 17α-propionate; CB-03-01) is a new topical and peripherally selective androgen antagonist[1].
Product Specifications
Product Name Alternative
Cortexolone 17 alpha-propionate-d6; Cortexolone 17α-propionate-d6; CB-03-01-d6
UNSPSC
12352211
Target
Androgen Receptor; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Others; Vitamin D Related/Nuclear Receptor
Field of Research
Endocrinology
Smiles
CCC(O[C@@]1(CC[C@]2([C@@]3(CC(C4=C(C(C([2H])(C[C@@]4([C@]3(CC[C@]12C)[H])C)[2H])=O)[2H])[2H])[H])[H])C(C([2H])(O)[2H])=O)=O
Molecular Formula
C24H28D6O5
Molecular Weight
408.56
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Trifu V, et al. Cortexolone 17-propionate 1% cream, a new potent antiandrogen for topical treatment of acne vulgaris. A pilot randomized, double-blind comparative study vs. placebo and tretinoin 005% cream. Br J Dermatol. 2011 Jul;165 (1) :177-83.|[3]Trifu V, et al. Cortexolone 17α-propionate 1% cream, a new potent antiandrogen for topical treatment of acne vulgaris. A pilot randomized, double-blind comparative study vs. placebo and tretinoin 0·05% cream. Br J Dermatol. 2011 Jul;165 (1) :177-83.|[4]Celasco G, et al. Biological profile of cortexolone 17alpha-propionate (CB-03-01), a new topical and peripherally selective androgen antagonist. Arzneimittelforschung. 2004;54 (12) :881-6.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
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