BACE1 Antibody

Responsible for the proteolytic processing of the amyloid precursor protein (APP) . Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. [UniProt]

Product Specifications

CAS Number

9007-83-4

Specifications

Western blot: 1:1000, IHC (Paraffin) : 1:10-1:50

UniProt

P56817

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

A portion of amino acids 38-70 from the human protein was used as the immunogen for this BACE1 antibody.

Clonality

Polyclonal

Isotype

Applications

WB, IHC, ELISA

Purity

Purified

Format

Purified

Buffer

In 1X PBS, pH 7.4, with 0.09% sodium azide

Reconstitution

Store at 4oC for up to one month. For long term, aliquot the BACE1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This BACE1 antibody is available for research use only.

Storage Conditions

Store at 4°C for up to one month. For long term, aliquot the BACE1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

In 1X PBS, pH 7.4, with 0.09% sodium azide

Applications Notes

The stated application concentrations are suggested starting amounts. Titration of the BACE1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.